New fungal infection discovered in China
Scientists uncovered a species of fungi that had never before been seen in humans. They say warmer temperatures could drive its evolution, for the worse.
![A gloved hand holds a petri dish with a culture of yeast](https://cdn.mos.cms.futurecdn.net/iipui4znZ6XwceMU5K6rm-320-80.jpg)
Scientists in China have discovered a previously unknown fungal pathogen that can infect humans.
The fungus, called Rhodosporidiobolus fluvialis, was found in clinical samples from two unconnected hospital patients. In experiments, the researchers found that the yeast was resistant to several first-line antifungal drugs at higher temperatures — around that of the human body. This temperature also gave rise to "hypervirulent mutants" capable of causing more-severe disease in lab mice.
The findings "support the idea that global warming can promote the evolution of new fungal pathogens," the researchers behind the discovery wrote in a report published June 19 in the journal Nature Microbiology.
The scientists made this discovery after examining fungi sampled from patients in 96 hospitals across China between 2009 and 2019. In all, 27,100 strains of fungi were collected and analyzed; of these, only R. fluvialis had never been seen in humans before.
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R. fluvialis was uncovered in the blood of two unconnected patients who, in addition to being infected with the yeast, had serious underlying health conditions. One patient was a 61-year-old who died in an intensive care unit (ICU) in Nanjing in 2013, and the other was an 85-year-old who died in 2016 after being treated in an ICU in Tianjin. The report doesn't note whether the fungal infection directly contributed to these patients' deaths or if they just happened to be infected at the time.
As part of their treatments, the patients were given common antifungal drugs, including fluconazole and caspofungin. Lab studies by the team later found that R. fluvialis is resistant to both these drugs.
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"This is a remarkable and truly unexpected finding, which bodes badly for the future," David Denning, a professor of infectious diseases at the University of Manchester in the U.K. who was not involved in the research, told Science.
Invasive fungal infections, which attack tissues deep in the body, mostly affect people whose immune systems are weakened, due to HIV infection or as a result of taking immunosuppressant drugs, for example. Notably, the 61-year-old infected with R. fluvialis had been immunosuppressed, and the 85-year-old had diabetes, which can hinder immune function.
However, rising global temperatures have driven fungi to adapt and extend their geographical ranges, making some more likely to come into contact with humans. Thus, new pathogens have emerged, including the drug-resistant Candida auris, which has been identified in more than 40 countries since its discovery in 2009. Meanwhile, the development of new antifungal drugs has largely stalled, leaving few options to fight resistant infections.
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In the new study, researchers sickened immunocompromised mice with R. fluvialis and found that some of the fungal cells rapidly evolved to grow more aggressively. The team then looked at the fungus in lab dishes kept around human body temperature — 98.6 degrees Fahrenheit (37 degrees Celsius). At that temperature, the yeast mutated 21 times faster than it did at room temperature, around 77 F (25 C).
The heat also made R. fluvialis more likely to become drug resistant. When exposed to the antifungal drug amphotericin B, the yeast developed resistance more quickly at body temperature than it did at room temperature.
If yeasts like R. fluvialis are more likely to become virulent and drug resistant at high temperatures, global warming could potentially drive the evolution of new, dangerous fungal pathogens, the team wrote in the paper.
But as for R. fluvialis, specifically, some scientists argue against jumping to worrisome conclusions. Matthew Fisher, a professor of fungal disease epidemiology at Imperial College London who was not involved in the research, told Science the yeast shouldn't yet be seen as a major, emerging threat.
"My kind of first feeling here is that there are unsurveyed environments in China where these yeasts dwell, and that these two patients have been unlucky enough to be exposed," he told Science. In short, there isn't evidence of R. fluvialis spreading widely through the populace, despite its concerning features.
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Emily is a health news writer based in London, United Kingdom. She holds a bachelor's degree in biology from Durham University and a master's degree in clinical and therapeutic neuroscience from Oxford University. She has worked in science communication, medical writing and as a local news reporter while undertaking journalism training. In 2018, she was named one of MHP Communications' 30 journalists to watch under 30. (emily.cooke@futurenet.com)